Nucleus Genomics launches genetic matchmaking: screen 1,000 conditions, find a compatible partner

Mar 14, 2025 · Full transcript · This transcript is auto-generated and may contain errors.

Featuring Kian Sadeghi

in Europe that's the real project Europe anyway we got Keon in the waiting room let's bring him in how you doing welcome to the Temple of Technology what up what's up man The Hooligans the mods of PODS I'm ready John I'm ready for you right now let's go let's go it's great to talk to you great to see you I don't think I've seen you in person since uh Miami uh but give me the breakdown tell the tell the fans who you are uh and what what nucleus is and then what you announced today yeah so my name is Keon founder CEO of a company called nucleus genomics where the world's most advanced DNA Health test single Swap single test you can screen for over a thousand conditions and today oh my God it's chaos in the headquarters in the best way okay we have launched genetic matchmaking okay so now you can family plan far more effectively you can make sure every single couple in this country has healthy children it is absolutely amazing it's already blowing up on Twitter John have you seen the video I have not seen video can you pull the video up right now can you pull the video up right now I will I will share with Ben and hopefully we can we can pull it up uh have you been are you in a relationship have you been testing this yourself have you been getting on the app dog are you dog fooding this I am dog Foody this real time it's funny because we we were thinking about like should we block same sex couples or not you know because we figured that in the future you should be able to Independent of sex you know be able to have you know children for now it is sex block so it has be male to female sorry about a lot of tech Bros out there I know that might be hard for some of you guys but when you find the one when you find the special someone you can do nucleus and it is going to be amazing what is the actual flow for nucleus is it uh cheek swab I mail it in break it that break Che swab yep you get get a DNA kit that looks like this you open it up inside there's a cheek swab you take the cheek swab you go sing a tube non-invasive you can do it at home no doctor's off is involved goes to laboratory laboratory processes the DNA outc comes a raw DNA file which then we run through all our analysis uh which is honestly like a a like this is people do not appreciate how much of a feat of science neran this is there's a couple people I have to thank here first and foremost Gregor mendal late 19th century thank you for thank you for playing with those P's he did not play this piece you know you know you know he he had like extraordinary statistical intuition you know he had no idea what DNA was he was completely abstracted there's no molecular basis just playing with the peas went all the way to the you know Hershey Chase experiment shot to that experiment wats in quick ien finding the structure of DNA of course a Human Genome Project right a massive government project billions of dollars in investment thousands of scientists this product is now live in anyone's hands it's a short line from Gregor mendal in 1866 to uh nucleus being promoted at the Jake Paul fight so you know he could see it now we'd be great uh um Ben you're you're live streaming right now let's see if this video works yeah yeah we got the video here this is a day I've been looking forward to for 4 and 1/2 years but really today's product announcement is the culmination of Decades of scientific medical and genomic progress spending thousands of scientists and billions of dollars in investment hence today I'm so excited to show you the next chapter of preventative health Family Planning through genetic matching imagine knowing every possible outcome for you and your partner's future children starting with their hereditary risks through nucleus you have the power to end preventable disease in your future family long before you even decide to have children to show you how easy this is I'm going to sync my results with my good friend Molly OA let's go hey Molly what's up perfect timing I just opened up my nucleus to see my results I've got to say the UI looks really good oh that's so nice you know we really spent as much time as possible to build beautiful products and by the way aren't you one of the first people who did nucleus I mean do you think maybe we're going to be a genetic match definitely let's find out seeing if you're a genetic match is almost as easy as seeing if you're a match on a dating app I'm going to show you exactly how here are my nucleus family results which just came out I haven't synced with Molly yet so you can actually see my kids may be at risk for Cystic Fibrosis but the only way to find if Molly and I are actually going to pass down this risk to our kids is by syncing our results let me show you how this works just click add partner and confirm that your partner's done nucleus Molly has of course so I click yes we're about to find out if we're a match Molly are you ready yep let's [Music] see oh my God we're a match this is amazing Molly are you still there shocking I have to break up okay uh well we'll come back to Molly later but about what just happened on the back end nucleus scanned our combined genomes for nearly a thousand conditions that that we could have unknowingly passed down to our children from here Molly and I can dive deeper into the specifics of our results in reality nine out of 10 parents have a genetic risk that they could pass down to their children and one in 25 people have a genetic marker for Cystic Fibrosis so what would happen if Molly had a genetic marker for Cystic Fibrosis we have good news we've been hard at work for something that we think will fundamentally change Family Planning forever we can't share too much yet but imagine if you could learn not just about the diseases you could pass down to your children but also whe they're going to look and act more like Mom or Dad more on that soon at nucleus we believe that anyone anywhere should have the choice to access genetic insights to make more informed decisions about their health okay so the big question uh do we have him back yeah yeah yeah you there oh I think we got to un mute him let's see we're juggling things can we hear you Keon okay I can hear you can you hear me yep fantastic back uh the big first thing that how was that video huh goes hard right yeah very clear very clear I I really liked how efficiently the everything's communicated the transitions are cool but it's not all style there's substance there very well executed good job when uh the big question uh John and I are both married but if somebody if one of our listeners is dating you know somebody when's the right time say all right pull out like let me see your cheek we got to do a quick swab you got to do a swab look look look look there's there's many ways in doing this right if you da someone already it's okay you know you do nuk list you see if you have a genetic risk or not if you're if you both have a genetic RIS for the same thing you can do IVF there's other reproductive options you're going to be good you know the risk exists so you can prevent the risk the whole point of genetics right but also there's a world where listen maybe you're a tech out there listening to this podcast you don't have the special someone yet no worries you sit down you say you know you know what college you go to you know they tell you whatever you say okay nice you know what do you do you know then you say have you done a nucleus test there you go there you go I mean you got to break it to them you gotta say listen you got to make sure the genes are aligned because why would you get into this business in the first place right you want to get deeper into it if the genetics are not matched right I mean you don't want to be car the same thing do you see people throwing up their nucleus results like on dating apps like just look just look at these look at fut May fut I mean I think I think we we believe in kind of individual liberty I think genetics should be integrated with dating apps and if someone you know opts in and should say hey I don't be match with someone who's also car for a rare genetic marker it's actually done in different communities the asosi Jewish Community they do this all the time actually don't match people who are the same rare genetic marker so 100% I think you should integrate dating apps do Mass preconception testing DNA is becoming as you guys know cheaper and cheaper and cheaper one of the greatest decrease in costs ever combining that with AI there's going to be magic Mass integration with different dating apps I think you're to save a lot of baby's lives what about flipping it around obviously the genetic markers for diseases are very you know you want to avoid those but you know I already have kids but I could imagine that my son when he goes to have his own CH child my future grandchildren uh might want to optimize for a grandchild who's you know going to be a future bodybuilder let's say and and we want to make sure that you know they're just matched up so they can go to the Arnold the most proud grandpa and just absolutely look diced you know massive put on 300 pounds of pure muscle and and he wants to make sure that his his wife is uh is setting their kids up for Success uh will nucleus help with that great question so first things first I'll say is John he has a good father because you're like seven foot tall than the jeans are good the je are good he already has already inherently he's good there um but you know it's funny you actually asked this because at the end of the video there I you know left a little teaser in there about something that's coming out let's just say you know there there's something about you know maybe you know you don't want to just simulate disease risk but also maybe want to simulate what your baby's going to look and to act like you know when you start thinking aboutum sequencing you can start maybe thinking about can you actually simulate procreation oh win wink nudge nudge and let's just say you know John we're shipping we're shipping like crazy it's like it's like hysteria in the nucleus headquarters we're building at the frontier of genetics you know I hear like sirens going off gongs being hit it's complete chaos in here yeah so so it feels like you know the the I think the the consensus now is at 2 three and me walk so you guys could uh take us to the moon like what like how far can you how far can you take this right because like the first step is like giving people the data and then you're then you're trying to like influence influence outcomes like how how much does the sort of nucleus platform expand what is the like 10 trillion dollar vision for the business because I know you're that ambitious yeah so you know it's like Blockbuster versus Netflix it's like you know Blackberry iPhone that's the moment that's happening in genomics right now and the beauty of the genome what everyone's starting to appreciate is that the basically Marvel of engineering and science that it is because if you think about it when you actually read someone's entire genome it's not just disease risk assessments that you can actually think about it starts to be talking about Family Planning about procreation simulation about what drugs actually work best for you what supplements work best for you and even about the longtail different traits you can analyze from from IQ all the way to muscle strength you start realizing that the integration of the genome simply has not happened yet in society right you if you take a poll of you know 300 Americans look how many have been sequenced right basically none of them have and you talk about one of the greatest Innovations ever which is the decrease in cost of sequined genome by far the single highest density uh highest consequential piece of health information that exists because it's literally your DNA it's the entire thing and it's not integrated in medicine in lifestyle or in dating I mean the opportunity is massive and this test today cost $400 I'll make a prediction right here on technology Brothers within five years this test couple dollars couple dollars I said couple dollars amazing amazing congratulations get so so last question uh is are we going to have a way to test if somebody's nice with it or got that dog in them or is cracked because you seem like you're you're definitely nice with it you definitely have that dog in and you see this interesting so we we have found consistently okay that Founders who do nucleus tend to be very high in their schizophrenic disposition okay so personally I'm in the 99 percentile I'm rocking it baby I'm seeing I'm telling you right now % that's how it is I swear you look at Alexis shout out my man Alexis one of our lead investors super high schizophrenic a lot of other Founders I know super high schop that's public by the way that's public by the way I'm not just exposing Alex Alex results are public I would never just expose public Alex there and so if you want you gota look to see what schizophrenic in fact one interesting study showed that they ran these different models across every single phenotype and they compared across different careers by far the highest predictive one was actually schizophrenia but it was for artist which is very similar to entrepreneurs though so you know that's something you do if you're low ADHD super low ADHD associated with doctors and lawyers so you know there's something there you know you got that dog in you maybe it's in your DNA I love it I love it well where can people go get it where can people order a test my nucleus.

comom myus.

com family if you're a couple you want to have healthy children that's where you should go T5 follow me on Twitter yeah Twitter amaz you're amazing I this was fun I I've actually we've never talked uh and I'd love to have you back on when there's whenever there's Gom news just bio correspond join join this exact link like don't even you don't even tell us just join the link hey there's news you tell us amazing man well congratulations on the launch we'll talk to you soon talk soon have a great day peace guys bye have a good weekend too amazing yeah I I think genetics might explain why a single inorganic blueberry would kill you on the spot and yet I could eat a credit card with a fork and knife and just be unaffected so I think we got Josh Dian coming in of microplastic haters yo yo how you