Cadence raises $100M Series C after showing AI can prevent 20 strokes a week and save Medicare $2.7M per week

Cadence raises $100M Series C

Cadence, a clinical AI company automating treatment of chronic disease, has closed a $100M Series C. The company manages nearly 100,000 patients across 21 leading US hospital systems, including Duke and Texas Health, and says it is currently saving Medicare $2.7M per week by preventing avoidable hospitalizations.

“We raised a $100,000,000 Series C. We have the privilege of managing 100,000 patients now nearly with a lot of the leading hospital systems in the country and preventing strokes and heart attacks. We're catching about 20 strokes a week right now before the patients know that they're having a stroke — just off of these agents doing symptom triage plus the data we have. Today, Cadence saves Medicare about $2,700,000 per week by preventing avoidable hospitalizations, and we're still very small scale relative to what this can become.”

How it works

Altchek frames the core problem in stark terms: fewer than 10% of the roughly 8 million US seniors with heart failure are on the right drugs, even though reaching the correct medication regimen extends lifespan by five to seven years on average. The bottleneck is operational — getting a patient to the right drugs typically requires five to seven medication adjustments per year, each tied to real-time monitoring of blood pressure, heart rate, and weight. Most physicians don't have the infrastructure to do it.

Cadence fills that gap. A physician orders the service, the patient receives FDA-cleared cellular-connected monitoring devices, and Cadence's AI agents — with human clinicians making final decisions — handle medication titration, symptom triage, and daily coaching. The average patient is 75 years old. Where a typical patient might have blood pressure checked four times a year at a clinic visit, Cadence patients generate readings on average 22 days a month.

That data density is doing real clinical work. Cadence says it is catching approximately 20 strokes per week before patients are aware they're having one, via a voice agent that calls patients within two and a half minutes of a dangerous reading, triages symptoms, and routes them to the appropriate level of care.

Scale and go-to-market

At 100,000 patients across 21 systems, Cadence estimates it is reaching only 3% of the eligible patients within its current hospital relationships. Altchek puts the total addressable population in the US at 10 to 30 million patients for the conditions Cadence currently covers.

The expansion playbook runs through three channels: growing from 21 hospital system partners to 100, deepening patient penetration within existing systems, and expanding payer relationships. Cadence already works with two of the largest payers in the country and has engaged CMS to document positive ROI.

General Catalyst and Summa Health

General Catalyst, a co-investor in the round, earlier this year closed its acquisition of Summa Health, a nonprofit hospital system that also serves as a major payer in its community. Altchek describes Summa as a testing ground for rapid technology modernization — and a natural fit for Cadence, given that Summa captures value on both the provider and payer sides of prevented hospitalizations.

Altchek draws a distinction that shapes the company's positioning: most health AI to date has targeted back-office automation — billing, revenue cycle, call centers. Cadence is using AI to deliver clinical care directly. With $2.7M in weekly Medicare savings at roughly 100,000 patients, the implied economics at 10x or 30x scale are what the Series C is being raised to chase.